Type 1 Autoimmune Pancreatitis (AIP) is a form of chronic pancreatitis characterized by an autoimmune inflammatory process, often associated with elevated serum IgG4 levels and systemic involvement, such as sclerosing cholangitis. It responds well to corticosteroid therapy, distinguishing it from other forms of pancreatitis and making accurate diagnosis crucial for effective treatment.

Type 1 Autoimmune Pancreatitis

Autoimmune inflammatory process

Elevated serum IgG4 levels

Systemic involvement refers to the participation or impact of a condition or process on multiple systems or organs within the body, often leading to widespread effects. It is crucial in understanding diseases that do not confine themselves to a single organ, necessitating a comprehensive approach for diagnosis and treatment.

Systemic Involvement

Sclerosing cholangitis is a chronic liver disease characterized by inflammation and scarring of the bile ducts, which can lead to liver damage and cirrhosis. It is often associated with inflammatory bowel disease, particularly ulcerative colitis, and may increase the risk of bile duct cancer.

Sclerosing Cholangitis

Corticosteroid therapy involves the use of steroid hormones to reduce inflammation and suppress the immune system, commonly used to treat conditions like asthma, arthritis, and autoimmune diseases. While effective, long-term use can lead to significant side effects, necessitating careful management and monitoring by healthcare professionals.

Corticosteroid Therapy

Chronic pancreatitis is a long-standing inflammation of the pancreas that alters its normal structure and functions, often leading to irreversible damage and pain. It is commonly caused by prolonged alcohol abuse, genetic factors, or autoimmune disorders and can result in complications such as diabetes and malabsorption of nutrients.

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