Neanderthal Interbreeding refers to the Genetic Exchange between Neanderthals and Anatomically Modern Humans, which occurred tens of thousands of years ago when their populations overlapped in Europe and Asia. This interbreeding has left a Genetic legacy in modern Non-African human populations, with about 1-2% of their DNA being of Neanderthal origin, influencing traits such as Immune Response and Skin Pigmentation.