ASC protein, also known as Apoptosis-associated Speck-like protein containing a CARD, is crucial in the formation of inflammasomes, which are multiprotein complexes involved in the activation of inflammatory responses. It acts as an adaptor protein, bridging the interaction between NLRP3 and pro-caspase-1, facilitating the maturation of pro-inflammatory cytokines like IL-1β and IL-18.

ASC Protein

Apoptosis-associated Speck-like protein

 inflammasomes

Multiprotein complexes

Inflammatory Responses

Adaptor protein

NLRP3 is a crucial component of the innate immune system, acting as a sensor that detects a wide range of pathogenic and stress signals to initiate the formation of the inflammasome, a multiprotein complex that activates inflammatory responses. Dysregulation of NLRP3 is implicated in various inflammatory diseases, making it a significant target for therapeutic interventions.

NLRP3

Pro-caspase-1 is an inactive precursor of caspase-1, an essential enzyme in the inflammatory response that processes pro-inflammatory cytokines like IL-1β and IL-18 into their active forms. Activation of pro-caspase-1 occurs within the inflammasome complex, a crucial component of the innate immune system's response to pathogens and cellular stress signals.

Pro-caspase-1

Maturation of pro-inflammatory cytokines

IL-1β is a pro-inflammatory cytokine that plays a critical role in the body's immune response, primarily by mediating inflammation and fever. It is involved in various diseases, including autoimmune disorders and chronic inflammatory conditions, making it a target for therapeutic interventions.

IL-1β

IL-18 is a pro-inflammatory cytokine that plays a crucial role in both innate and adaptive immune responses, often working in synergy with IL-12 to induce IFN-gamma production. It is involved in various inflammatory and autoimmune diseases, making it a target for therapeutic interventions aimed at modulating the immune system.

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