Nucleotide excision repair (NER) is a vital DNA repair mechanism that removes bulky, helix-distorting lesions such as those caused by UV light and chemical carcinogens, ensuring genomic stability. It involves the recognition of damage, excision of a short single-stranded DNA segment containing the lesion, and synthesis of a new DNA strand to fill the gap.

Nucleotide Excision

Nucleotide Excision Repair (NER) is a crucial DNA repair mechanism that removes bulky DNA lesions, such as those caused by UV radiation, by excising a short single-stranded DNA segment containing the damage and filling in the gap with newly synthesized DNA. This process is vital for maintaining genomic stability and preventing mutations that can lead to diseases like cancer.

Nucleotide Excision Repair

DNA repair mechanism

Bulky lesions

Helix-distorting Lesions

UV light

Chemical carcinogens are substances that can lead to cancer by inducing mutations or otherwise interfering with normal cellular processes. Understanding and controlling exposure to these chemicals is crucial in preventing cancer development and safeguarding public health.

Chemical Carcinogens

Genomic stability refers to the maintenance of DNA sequence and chromosomal integrity across cell divisions, ensuring proper cellular function and preventing diseases such as cancer. It is achieved through a range of cellular mechanisms that repair DNA damage, regulate cell cycle checkpoints, and maintain telomere length.

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