Intrinsic renal failure, also known as intrinsic acute kidney injury, occurs when there is direct damage to the kidney tissue due to conditions such as acute tubular necrosis, glomerulonephritis, or interstitial nephritis. It is characterized by a sudden decrease in kidney function, leading to the accumulation of waste products in the blood and potential electrolyte imbalances.

Intrinsic Renal Failure

Intrinsic renal failure

intrinsic acute kidney injury

Direct damage to kidney tissue

Acute tubular necrosis (ATN) is a kidney disorder involving the death of tubular epithelial cells, which leads to acute kidney injury and is often caused by ischemia or nephrotoxic agents. It is characterized by a rapid decline in renal function, leading to an increase in serum creatinine and a decrease in urine output.

acute tubular necrosis

Glomerulonephritis is a group of kidney diseases characterized by inflammation of the glomeruli, leading to impaired kidney function and potential renal failure. It can be caused by infections, autoimmune disorders, or other systemic diseases, and is diagnosed through clinical evaluation, laboratory tests, and sometimes renal biopsy.

glomerulonephritis

Interstitial nephritis is an inflammatory condition affecting the kidney's interstitial tissue, often caused by medications, infections, or autoimmune disorders. It can lead to acute kidney injury, presenting with symptoms like fever, rash, and eosinophilia, and is typically diagnosed through urine analysis and kidney biopsy.

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