The entorhinal cortex is a critical region of the brain involved in memory, navigation, and the processing of spatial information, serving as a major interface between the hippocampus and neocortex. It plays a significant role in the formation and retrieval of episodic memories and is one of the first areas affected in Alzheimer's disease, leading to memory impairment.

Entorhinal Cortex

entorhinal cortex

critical region of the brain

Memory is a cognitive process that involves encoding, storing, and retrieving information, allowing humans to retain past experiences and knowledge for future use. It is a complex system influenced by biological, psychological, and environmental factors, crucial for learning, decision-making, and identity formation.

memory

Navigation is the process of accurately determining one's position and planning a route to a desired location, utilizing various tools and techniques to ensure safe and efficient travel. It encompasses a wide range of methods from traditional celestial navigation to modern GPS technology, adapting to different environments such as land, sea, air, and space.

navigation

processing of spatial information

major interface

The hippocampus is a critical brain structure involved in the formation of new memories and is also associated with learning and emotions. It plays a crucial role in spatial navigation and is one of the first regions to suffer damage in Alzheimer's disease, leading to memory loss and disorientation.

hippocampus

The neocortex is the part of the mammalian brain involved in higher-order brain functions such as sensory perception, cognition, and generation of motor commands. It is characterized by its layered structure and is responsible for the advanced cognitive abilities that distinguish humans and other mammals from other species.

neocortex

Formation of episodic memories

retrieval of episodic memories

Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes, primarily affecting older adults. It is the most common cause of dementia, with complex pathophysiology involving amyloid-beta plaques, tau tangles, and neuroinflammation, leading to neuronal death and brain atrophy.

Alzheimer's disease

Memory impairment refers to a decline in the ability to remember information, which can affect daily functioning and quality of life. It can result from various causes, including neurological disorders, brain injuries, psychological conditions, or aging, and may require different diagnostic and therapeutic approaches depending on the underlying cause.

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