The VEGF signaling pathway is crucial for the regulation of angiogenesis, the process by which new blood vessels form from existing ones, and is pivotal in both physiological and pathological contexts such as cancer and ischemic diseases. It involves the binding of Vascular Endothelial Growth Factor (VEGF) to its receptors on endothelial cells, triggering a cascade of downstream signaling pathways that promote cell proliferation, migration, and survival.