Selective IgA Deficiency is the most common primary immunodeficiency, characterized by a significant reduction or absence of IgA antibodies, which are crucial for mucosal immunity. While many individuals remain asymptomatic, it can lead to increased susceptibility to infections, allergies, and autoimmune diseases.

Selective IgA Deficiency

Primary immunodeficiency refers to a group of disorders where part of the body's immune system is missing or does not function properly, leading to an increased susceptibility to infections. These conditions are usually inherited and can range from mild to severe, affecting individuals from infancy through adulthood.

Primary Immunodeficiency

IgA Antibodies

Mucosal immunity is the immune response that protects the body's mucous membranes, which are the primary entry points for many pathogens. It involves specialized immune cells and antibodies, particularly Immunoglobulin A (IgA), to prevent infection and maintain the balance of the microbiome at these critical interfaces.

Mucosal Immunity

Susceptibility to infections

Allergies are hypersensitive immune responses to substances that are typically harmless to most people, known as allergens. They can cause a range of symptoms from mild discomfort to severe reactions, and are managed through avoidance, medication, and sometimes immunotherapy.

Allergies

Autoimmune diseases occur when the immune system mistakenly attacks the body's own cells, leading to chronic inflammation and tissue damage. These diseases can affect almost any part of the body and are influenced by genetic, environmental, and hormonal factors.

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