The RNA recognition motif (RRM) is a highly conserved protein domain that binds to RNA molecules, playing a crucial role in post-transcriptional regulation of gene expression. It is characterized by a beta-sheet structure that interacts with RNA through sequence-specific and structure-specific contacts, influencing processes like splicing, polyadenylation, and RNA stability.

RNA Recognition Motif

RNA recognition motif

A protein domain is a distinct functional and structural unit within a protein, often responsible for a particular function or interaction, and can evolve, function, and exist independently of the rest of the protein chain. Domains are critical for the modular architecture of proteins, allowing for the combination of different domains to create proteins with diverse functions.

protein domain

RNA molecules

Post-transcriptional regulation refers to the control of gene expression at the RNA level, occurring after transcription has taken place. This process is crucial for the fine-tuning of gene expression and involves mechanisms such as RNA splicing, editing, transport, stability, and translation efficiency.

post-transcriptional regulation

Gene expression is the process by which information from a gene is used to synthesize a functional gene product, typically proteins, which ultimately determine cellular function and phenotype. This process is tightly regulated at multiple levels, including transcription, RNA processing, translation, and post-translational modifications, to ensure proper cellular function and response to environmental cues.

gene expression

The beta-sheet structure is a fundamental element of protein secondary structure characterized by beta strands linked laterally by at least two or three backbone hydrogen bonds, forming a sheet-like arrangement. This structure contributes to the stability and functionality of proteins and is crucial in the formation of protein complexes and aggregation-related diseases like Alzheimer's.

beta-sheet structure

Sequence-specific contacts

structure-specific contacts

Splicing is a molecular biology process where introns are removed and exons are joined together in pre-mRNA to form mature mRNA, which is then translated into proteins. This process is essential for gene expression regulation and allows for alternative splicing, increasing protein diversity from a single gene.

splicing

Polyadenylation is a post-transcriptional modification process in eukaryotic cells where a poly(A) tail is added to the 3' end of an RNA molecule, enhancing its stability and facilitating its transport and translation. This process is crucial for the regulation of gene expression and the maturation of messenger RNA (mRNA).

polyadenylation

RNA stability refers to the lifespan of RNA molecules in a cell, influencing gene expression and cellular function by determining how long RNA transcripts are available for translation. Factors affecting RNA stability include sequence elements, RNA-binding proteins, and environmental conditions, making it a crucial aspect of post-transcriptional regulation.

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