Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, originating from the lining of the proximal convoluted tubule. It is often asymptomatic in early stages, making it challenging to diagnose until it has metastasized, necessitating a combination of surgical, targeted, and immunotherapy treatments for management.

Renal Cell Carcinoma

Kidney cancer, also known as renal cancer, is a disease where kidney cells become malignant and grow uncontrollably, forming a tumor. Early detection and treatment are crucial, as the disease can spread to other parts of the body if not addressed promptly.

Kidney Cancer

The proximal convoluted tubule (PCT) is a critical segment of the nephron in the kidney where the reabsorption of water, ions, and nutrients from the filtrate back into the bloodstream occurs. It plays a vital role in maintaining homeostasis by reclaiming approximately 65% of the glomerular filtrate volume, including glucose, amino acids, and bicarbonate, while secreting waste products into the tubular fluid.

Proximal Convoluted Tubule

Asymptomatic early stages

Diagnosis of RCC

Metastasis is the process by which cancer cells spread from the primary tumor to distant organs, establishing secondary tumors, and is the leading cause of cancer-related mortality. Understanding the mechanisms of metastasis is crucial for developing effective treatments to prevent and combat cancer progression.

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