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Phase I And Phase II Metabolism
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Summary
Phase I and
Phase II Metabolism
are crucial processes in
Drug Metabolism
, where Phase I involves the introduction or exposure of
Functional groups on drugs
via oxidation, reduction, or hydrolysis, and Phase II involves
Conjugation Reactions
that increase the
Water solubility of drugs
for excretion. These processes are essential for the detoxification and
Elimination of xenobiotics
, affecting
Drug Efficacy
and safety.
Concepts
Cytochrome P450 Enzymes
Oxidation
Reduction
Hydrolysis
Conjugation Reactions
Glucuronidation
Sulfation
Acetylation
Methylation
Detoxification
Xenobiotics
Drug Metabolism
Enzyme Induction
Enzyme Inhibition
Bioavailability
Cellular Detoxification
Detoxifying Enzymes
Estrogen Metabolism
Infant Drug Metabolism
Relevant Degrees
General Toxicology 100%
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