Parasitic Vacuole Formation is a critical process by which Intracellular parasites, such as Plasmodium and Toxoplasma, create a Protective niche within Host Cells, allowing them to evade Host immune responses and facilitate Nutrient Acquisition. This process involves the Modification of host cell membranes and the recruitment of host and parasite proteins to establish a Functional compartment for Parasite survival and replication.