Malaria Vaccine Development focuses on creating Effective immunization strategies to combat the Plasmodium Parasites, which are transmitted by Anopheles Mosquitoes and cause significant Morbidity And Mortality worldwide. Despite challenges such as the Complex life cycle of the parasite and Antigenic Variation, recent advances have led to the approval of the first malaria vaccine, RTS,S/AS01, which provides Partial protection and marks a significant milestone in Global health efforts.