Lipophilicity refers to the chemical property of a compound to dissolve in fats, oils, lipids, and non-polar solvents, which is crucial for the absorption, distribution, metabolism, and excretion of drugs. It is a key factor in drug design, influencing the permeability of compounds through biological membranes and their bioavailability.

Lipophilicity

chemical property

dissolve in fats

Dissolve in oils

Dissolve in lipids

Dissolve in non-polar solvents

Absorption of drugs

Distribution of drugs

Metabolism of drugs

excretion of drugs

Drug design is the process of discovering and developing new medications based on the knowledge of a biological target. It involves the use of computational tools to predict how a drug interacts with its target and optimize its efficacy and safety profile.

drug design

permeability of compounds

Biological membranes are dynamic, selectively permeable barriers that separate the interior of cells from their external environment, playing critical roles in maintaining homeostasis and facilitating communication and transport. Composed primarily of a lipid bilayer with embedded proteins, they are essential for processes such as signal transduction, energy conversion, and molecular transport.

biological membranes

Bioavailability is the proportion of a drug or other substance that enters the bloodstream when introduced into the body and is thus able to have an active effect. It is a critical pharmacokinetic property that influences the efficacy and safety of medications and nutrients.

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