Lipid peroxidation is a process in which free radicals attack lipids containing carbon-carbon double bond(s), particularly polyunsaturated fatty acids, leading to cell membrane damage and contributing to various diseases. This oxidative degradation of lipids results in the formation of reactive aldehydes, such as malondialdehyde, which can further propagate cellular damage and inflammation.

Lipid Peroxidation

Lipid peroxidation

Free radicals are highly reactive molecules with unpaired electrons, which can cause oxidative stress by damaging cells, proteins, and DNA. They play a dual role in the body, contributing to both normal physiological processes and the development of various diseases, including cancer and aging-related disorders.

free radicals

Lipids containing carbon-carbon double bond(s)

Polyunsaturated fatty acids (PUFAs) are essential fats that the human body cannot synthesize, requiring them to be obtained through diet, and they play a crucial role in brain function and cell growth. They are known for their potential health benefits, including reducing inflammation and lowering the risk of heart disease.

polyunsaturated fatty acids

cell membrane damage

various diseases

oxidative degradation of lipids

reactive aldehydes

malondialdehyde

Cellular damage refers to the harm inflicted on cells due to various factors such as oxidative stress, radiation, toxins, and infections, potentially leading to cell dysfunction or death. Understanding cellular damage is crucial for developing therapies to prevent or repair tissue injury and mitigate diseases linked to cellular deterioration.

cellular damage

Inflammation is the body's complex biological response to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective attempt to remove the injurious stimuli and initiate the healing process. While acute inflammation is a vital part of the immune response, chronic inflammation can contribute to various diseases, including arthritis, cardiovascular diseases, and certain cancers.

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