The inhibition constant (Ki) is a quantitative measure of the potency of an inhibitor in binding to an enzyme or receptor, reflecting the strength of the inhibitor's effect in preventing a substrate from binding. A lower Ki value indicates a more potent inhibitor, as it requires a lower concentration to effectively inhibit the target enzyme or receptor activity.

Inhibition Constant (Ki)

The inhibition constant (Ki) is a measure of how effectively an inhibitor can bind to an enzyme or receptor, indicating the potency of the inhibitor. A lower Ki value signifies a more potent inhibitor, as it requires a lower concentration to achieve the same level of inhibition as an inhibitor with a higher Ki value.

inhibition constant

potency of an inhibitor

binding to an enzyme

Binding to a receptor

strength of the inhibitor's effect

preventing a substrate from binding

lower Ki value

more potent inhibitor

lower concentration to effectively inhibit

Target enzyme activity

Target receptor activity

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