Hepatocyte transplantation is a promising therapeutic approach for liver diseases, offering an alternative to whole organ transplantation by infusing isolated liver cells into the patient. It aims to restore liver function and bridge patients to liver regeneration or transplantation, although challenges such as cell sourcing, engraftment, and long-term function remain.

Hepatocyte Transplantation

Therapeutic Approach

Liver diseases encompass a range of conditions affecting the liver, including hepatitis, cirrhosis, and fatty liver disease, which can lead to liver failure if untreated. They are often caused by factors such as viral infections, alcohol abuse, and metabolic disorders, and require early diagnosis and management to prevent severe outcomes.

Liver Diseases

Whole organ transplantation

Isolated liver cells

Restore liver function

Bridge patients to liver regeneration

Liver regeneration is a unique biological process where the liver can regrow to its original size and restore function even after significant tissue loss. This remarkable ability is driven by the proliferation of hepatocytes and other liver cell types, orchestrated by complex signaling pathways and growth factors.

Liver Regeneration

Cell sourcing

Engraftment is the process by which transplanted stem cells, typically from bone marrow or peripheral blood, begin to grow and produce healthy blood cells in the recipient's body. It is a critical phase in stem cell transplantation, determining the success of the procedure and the patient's recovery from conditions like leukemia or lymphoma.

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