The endothelial pump is a critical mechanism in the cornea, where endothelial cells actively transport ions to maintain corneal transparency by regulating stromal hydration. Dysfunction in this pump can lead to corneal edema and vision impairment, highlighting its importance in ocular health.

Endothelial Pump

Critical mechanism

Endothelial cells form the inner lining of blood vessels, playing a crucial role in vascular biology by regulating blood flow, vessel permeability, and immune function. They are pivotal in angiogenesis, inflammation, and maintaining homeostasis, and their dysfunction is linked to various cardiovascular diseases.

Endothelial Cells

Transport ions

Corneal transparency is essential for clear vision, as it allows light to pass through the cornea and reach the retina without scattering. This transparency is maintained by the unique arrangement of collagen fibers, the absence of blood vessels, and the active regulation of corneal hydration by endothelial cells.

Corneal Transparency

Regulating stromal hydration

Dysfunction in this pump

Corneal edema is a condition characterized by swelling of the cornea due to fluid accumulation, often resulting from endothelial dysfunction, trauma, or inflammation. It can lead to blurred vision and discomfort, requiring prompt diagnosis and management to prevent long-term visual impairment.

Corneal Edema

Vision impairment refers to a significant limitation of visual capability resulting from disease, trauma, or congenital conditions that cannot be corrected by standard glasses or contact lenses. It affects a person's ability to perform everyday activities and can vary from mild vision loss to complete blindness.

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