Drug-Induced Hypersensitivity Syndrome (DIHS), also known as Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), is a severe, potentially life-threatening reaction characterized by a combination of skin eruptions, fever, lymphadenopathy, hematological abnormalities, and internal organ involvement. Prompt identification and discontinuation of the offending drug, along with supportive care and sometimes systemic corticosteroids, are crucial for managing this condition and preventing long-term complications.