Desmosterol is a crucial intermediate in the biosynthesis of cholesterol, playing a significant role in the body's lipid metabolism. Its accumulation is associated with desmosterolosis, a rare genetic disorder that affects cholesterol homeostasis and can lead to developmental abnormalities.

Desmosterol

Intermediate in the biosynthesis of cholesterol

Lipid metabolism encompasses the processes involved in the synthesis and degradation of lipids in cells, crucial for energy storage, membrane structure, and signaling. It includes pathways like fatty acid oxidation and synthesis, cholesterol metabolism, and the regulation of lipid levels in the body, impacting health conditions such as obesity, cardiovascular disease, and metabolic syndrome.

Lipid Metabolism

Accumulation refers to the gradual process of gathering or amassing resources, wealth, or information over time, often resulting in significant growth or change. It plays a crucial role in various fields, from economics and finance to environmental science and personal development, influencing both individual and collective progress.

Accumulation

Desmosterolosis

Rare genetic disorder

Cholesterol homeostasis is the balance maintained by the body to regulate cholesterol levels, ensuring adequate cellular function while preventing excessive accumulation that could lead to cardiovascular diseases. This balance is achieved through a complex interplay of dietary intake, endogenous synthesis, cellular uptake, and excretion processes, all tightly regulated by feedback mechanisms involving liver and intestinal cells.

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