Dermal fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the skin, leading to thickening and scarring. It is often associated with chronic inflammatory conditions, wound healing, and diseases like scleroderma, impacting skin elasticity and function.

Dermal Fibrosis

Pathological condition

Excessive deposition of collagen

Extracellular matrix components

Thickening and scarring

Chronic inflammatory conditions are long-term health disorders characterized by persistent inflammation, which can lead to tissue damage and contribute to the development of various diseases such as arthritis, cardiovascular disease, and diabetes. These conditions are often driven by a combination of genetic, environmental, and lifestyle factors, requiring comprehensive management strategies to control inflammation and prevent complications.

Chronic Inflammatory Conditions

Wound healing is a complex physiological process involving a series of overlapping stages: hemostasis, inflammation, proliferation, and remodeling, each critical for restoring tissue integrity. Effective healing requires a coordinated response from various cell types, growth factors, and extracellular matrix components, with disruptions potentially leading to chronic wounds or excessive scarring.

Wound Healing

Scleroderma is an autoimmune disease characterized by the hardening and tightening of the skin and connective tissues due to excessive collagen production. It can affect internal organs and lead to serious complications, with symptoms varying widely among individuals.

Scleroderma

Skin elasticity refers to the skin's ability to return to its original shape after being stretched or compressed, which is primarily influenced by the proteins elastin and collagen in the dermis layer. As we age, the production of these proteins decreases, leading to reduced elasticity and the formation of wrinkles and sagging skin.

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