Ataxia Telangiectasia Mutated (ATM) protein is a critical regulator of the cellular response to DNA damage, particularly in detecting and repairing double-strand breaks, thus ensuring genomic stability. Mutations in the ATM gene can lead to Ataxia Telangiectasia, a rare, neurodegenerative, autosomal recessive disorder characterized by issues such as neuronal degeneration, immunodeficiency, and increased cancer susceptibility.