5-alpha reductase is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen, playing a crucial role in male sexual development and conditions like androgenetic alopecia and benign prostatic hyperplasia. Inhibitors of 5-alpha reductase, such as finasteride, are used therapeutically to manage these conditions by reducing DHT levels.

5-alpha Reductase

5-alpha reductase

Testosterone is a steroid hormone primarily produced in the testes in males and ovaries in females, playing a crucial role in the development of male reproductive tissues and secondary sexual characteristics. It also influences muscle mass, bone density, and mood regulation, making it essential for overall health and well-being.

testosterone

Dihydrotestosterone (DHT) is a potent androgen hormone derived from testosterone that plays a crucial role in the development of male characteristics and is implicated in conditions like androgenetic alopecia and benign prostatic hyperplasia. It is formed by the action of the enzyme 5-alpha-reductase and has a higher binding affinity for androgen receptors than testosterone itself.

dihydrotestosterone

potent androgen

male sexual development

Androgenetic alopecia, commonly known as male or female pattern baldness, is a genetically determined condition characterized by progressive hair thinning and loss due to the miniaturization of hair follicles influenced by androgens. It is the most common form of hair loss, affecting a significant portion of the population and often having a profound psychological impact on those affected.

androgenetic alopecia

Benign prostatic hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland, commonly affecting older men, leading to urinary symptoms such as difficulty in starting urination and increased frequency. It is caused by hormonal changes and can be managed through lifestyle modifications, medications, or surgical interventions depending on severity.

benign prostatic hyperplasia

Inhibitors of 5-alpha reductase

Finasteride is a medication primarily used to treat male pattern baldness and benign prostatic hyperplasia by inhibiting the conversion of testosterone to dihydrotestosterone (DHT). It is important to be aware of potential side effects, including sexual dysfunction and depression, and it is contraindicated in pregnancy due to risks of birth defects.

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