Interleukin-5 (IL-5) is a cytokine primarily involved in the growth, differentiation, and activation of eosinophils, playing a crucial role in the immune response and in the pathogenesis of allergic diseases such as asthma. Targeting IL-5 with monoclonal antibodies has become a therapeutic strategy for treating eosinophilic disorders by reducing eosinophil levels and activity.

IL-5

Interleukin-5

Cytokines are small proteins crucial for cell signaling, particularly in immune responses, where they help regulate the balance between humoral and cell-based immunity. They play a role in inflammation, infection response, and various diseases, making them critical targets for therapeutic interventions.

cytokine

Eosinophils are a type of white blood cell that play a crucial role in the body's immune response, particularly in combating parasitic infections and mediating allergic reactions. They are characterized by their bilobed nuclei and the presence of large granules that contain proteins toxic to parasites and host tissues.

eosinophils

The immune response is the body's defense mechanism against pathogens, involving a complex interplay between innate and adaptive immunity. It includes the recognition of foreign antigens, activation of immune cells, and the elimination of pathogens, while also maintaining tolerance to self-antigens to prevent autoimmunity.

immune response

pathogenesis of allergic diseases

Asthma is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to symptoms such as wheezing, shortness of breath, chest tightness, and coughing. Effective management typically involves avoiding triggers, monitoring lung function, and using medications such as inhaled corticosteroids and bronchodilators to control and prevent symptoms.

asthma

Monoclonal antibodies are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system's attack on cells. They are highly specific to a particular antigen, making them powerful tools in the treatment of diseases such as cancer, autoimmune disorders, and infectious diseases.

monoclonal antibodies

A therapeutic strategy is a systematic plan designed to treat a disease or condition, often involving a combination of therapies tailored to individual patient needs. It encompasses the selection, timing, and integration of interventions to optimize patient outcomes and minimize adverse effects.

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