Hyperacute rejection is a severe immune response that occurs within minutes to hours after transplanting an organ, primarily due to pre-existing antibodies in the recipient's blood that recognize the donor organ as foreign. This immediate rejection is characterized by thrombosis and necrosis of the transplanted tissue, making it a critical concern in organ transplantation.

Hyperacute Rejection

Hyperacute rejection

severe immune response

transplanting an organ

pre-existing antibodies

recipient's blood

donor organ

foreign

immediate rejection

Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system, which can lead to serious conditions like stroke, heart attack, or pulmonary embolism. Understanding the risk factors, such as immobility, genetic predisposition, and certain medical conditions, is crucial for prevention and management.

thrombosis

Necrosis is the premature death of cells in living tissue caused by external factors such as trauma, infection, or toxins, resulting in unregulated digestion of cell components. Unlike apoptosis, necrosis often triggers an inflammatory response due to the release of intracellular contents into the surrounding tissue.

necrosis

transplanted tissue

Organ transplantation is a medical procedure where a failing or damaged organ in the human body is replaced with a healthy organ from a donor, which can be either living or deceased. This life-saving intervention requires careful matching of donor and recipient tissues, immunosuppressive therapy to prevent rejection, and addresses ethical, legal, and logistical challenges in the allocation of scarce resources.

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