Gene knockdown is a technique used to reduce the expression of a specific gene, allowing researchers to study the gene's function by observing the effects of its decreased activity. This method is commonly achieved through RNA interference (RNAi) or antisense oligonucleotides, providing a powerful tool for functional genomics and therapeutic research.

Gene Knockdown

Specific gene

Gene's function

Decreased activity

RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, effectively silencing targeted gene activity. This mechanism is crucial for regulating gene expression, defending against viral infections, and has potential applications in gene therapy and research.

RNA Interference

RNAi

Antisense oligonucleotides are short, synthetic strands of nucleic acids designed to bind to specific RNA molecules, effectively blocking the production of disease-causing proteins. This innovative approach offers a targeted method for treating genetic disorders, cancers, and viral infections by directly interfering with the genetic information flow.

Antisense Oligonucleotides

Functional genomics is a field of molecular biology that aims to describe gene functions and interactions by focusing on the dynamic aspects of genome activity, such as gene transcription, translation, and regulation. It leverages high-throughput techniques to analyze the roles and relationships of large numbers of genes simultaneously, providing insights into complex biological processes and disease mechanisms.

Concepts

Relevant Degrees

Your Lessons