Endothelial rejection is a form of graft rejection that primarily affects the corneal endothelium, leading to graft failure if not promptly addressed. It is characterized by immune-mediated damage, often presenting with symptoms such as decreased vision, corneal edema, and the presence of keratic precipitates.

Endothelial Rejection

Graft rejection is an immune response triggered when the recipient's immune system recognizes the transplanted tissue as foreign and attacks it, leading to the failure of the graft. This process is mediated by T-cells and antibodies that target the donor antigens, necessitating immunosuppressive therapy to prevent or mitigate rejection.

Graft Rejection

The corneal endothelium is a single layer of specialized, flattened cells located on the inner surface of the cornea, playing a crucial role in maintaining corneal transparency by regulating fluid and solute transport between the aqueous humor and the corneal stroma. Damage or dysfunction of this layer can lead to corneal edema and vision impairment, necessitating medical intervention or corneal transplantation.

Corneal Endothelium

Graft failure refers to the unsuccessful integration or rejection of transplanted tissue or organs by the recipient's body, often due to immunological incompatibility or surgical complications. It is a critical concern in transplant medicine, necessitating precise matching and immunosuppressive strategies to enhance graft survival.

Graft Failure

Immune-mediated damage

Decreased vision

Corneal edema is a condition characterized by swelling of the cornea due to fluid accumulation, often resulting from endothelial dysfunction, trauma, or inflammation. It can lead to blurred vision and discomfort, requiring prompt diagnosis and management to prevent long-term visual impairment.

Corneal Edema

Keratic precipitates are cellular deposits on the corneal endothelium that are commonly associated with uveitis and other inflammatory conditions of the eye. They vary in size and appearance, which can provide clues to the underlying cause and duration of the inflammation.

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