Cushing's Syndrome is a disorder caused by prolonged exposure to high levels of cortisol, often due to the use of corticosteroid medications or tumors that produce cortisol or adrenocorticotropic hormone (ACTH). It is characterized by symptoms such as weight gain, particularly around the abdomen and face, high blood pressure, and skin changes, and requires careful diagnosis and management to address the underlying cause and mitigate associated health risks.