Class switch recombination (CSR) is a biological mechanism in B cells that changes an antibody's isotype, allowing the immune system to produce antibodies with different effector functions without altering antigen specificity. This process is crucial for adaptive immunity, enabling a more versatile and effective immune response against pathogens.

Class Switch Recombination

Class switch recombination

biological mechanism

B cells are a type of white blood cell crucial to the adaptive immune system, responsible for producing antibodies that neutralize pathogens. They originate in the bone marrow and can differentiate into memory B cells or plasma cells, providing long-term immunity and rapid response upon re-exposure to antigens.

B cells

antibody's isotype

The immune system is a complex network of cells, tissues, and organs that work together to defend the body against harmful pathogens and maintain overall health. It involves both innate and adaptive responses, which recognize and neutralize foreign invaders while also retaining memory for faster future responses.

immune system

antibodies with different effector functions

Antigen specificity refers to the ability of the immune system to recognize and respond to specific antigens, which are unique molecules or molecular patterns on pathogens or foreign substances. This specificity is crucial for the immune response, as it allows the immune system to distinguish between self and non-self, targeting only harmful invaders without attacking the body's own cells.

antigen specificity

Adaptive immunity is a highly specialized and systemic response that develops as a result of exposure to specific antigens, providing long-lasting protection and immunological memory. It involves the activation of lymphocytes, including T cells and B cells, which recognize and remember pathogens, allowing for a more efficient and rapid response upon subsequent exposures.

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