ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) is a powerful technique used to assess chromatin accessibility across the genome, providing insights into regulatory elements and gene expression patterns. By employing a transposase enzyme to insert sequencing adapters into regions of open chromatin, ATAC-seq allows for the identification of active regulatory regions in various cell types and conditions with high sensitivity and resolution.

ATAC-seq

Assay for Transposase-Accessible Chromatin using sequencing

Chromatin accessibility refers to the ease with which DNA-binding proteins can access genomic DNA, influencing gene expression and regulation. It is a dynamic property affected by chromatin structure, histone modifications, and the presence of chromatin remodelers, playing a critical role in cellular differentiation and response to environmental signals.

chromatin accessibility

The genome is the complete set of genetic material in an organism, encoding all the information necessary for its growth, development, and functioning. It consists of DNA sequences that include both genes and non-coding regions, influencing traits and biological processes through complex interactions.

genome

Regulatory elements are DNA sequences that control the expression of genes by serving as binding sites for transcription factors and other proteins. These elements are crucial for orchestrating gene expression patterns during development and in response to environmental stimuli.

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