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Concept
Antigen Persistence
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Concept
T Cell Exhaustion
T cell exhaustion
is a
state of dysfunction
that arises in T cells during
chronic infections
and cancer, characterized by a
progressive loss of function
and
sustained expression of inhibitory receptors
. This phenomenon limits the
immune system's ability
to effectively combat
persistent antigens
, posing a challenge for immunotherapy and
vaccine development
.
3