Scavenger Receptor Class B Type I (SR-BI) is a cell surface receptor primarily known for its role in mediating the selective uptake of high-density lipoprotein (HDL) cholesterol, which is crucial for cholesterol homeostasis and cardiovascular health. Beyond lipid transport, SR-BI is also involved in various physiological processes, including steroidogenesis, immune response, and pathogen recognition, making it a significant target for therapeutic interventions in atherosclerosis and other diseases.