Myasthenia Gravis is an autoimmune neuromuscular disorder characterized by weakness and rapid fatigue of voluntary muscles due to the interruption of communication between nerves and muscles. It is primarily caused by antibodies that block or destroy nicotinic acetylcholine receptors at the neuromuscular junction, impairing muscle contraction.

Myasthenia Gravis

autoimmune neuromuscular disorder

weakness

rapid fatigue

voluntary muscles

interruption of communication

nerves and muscles

Antibodies are specialized proteins produced by the immune system that recognize and neutralize pathogens such as bacteria and viruses. They play a crucial role in the body's defense mechanism by specifically binding to antigens, marking them for destruction or neutralization by other immune cells.

antibodies

nicotinic acetylcholine receptors

The neuromuscular junction is a specialized synapse between a motor neuron and a muscle fiber that facilitates the transmission of nerve impulses, leading to muscle contraction. It plays a critical role in translating neural signals into mechanical movement, essential for voluntary and reflexive actions.

neuromuscular junction

Muscle contraction is a complex physiological process where muscle fibers generate tension through the interaction of actin and myosin filaments, driven by the hydrolysis of ATP. This process is regulated by calcium ions and involves intricate signaling pathways that ensure precise control of muscle movement and force generation.

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